Welcome to the upcoming CMYC mini-seminar
- Date: Friday, February 20th
- Time: 11:00 – 13:00
- Location: Auditorium 4, BB-bygget
with the following two presenters:
11:00 –12:00 Assoc. Prof. Francesca Sacco, Department of Biology, University of Rome Tor Vergata
“A systems biology approach to identify vulnerabilities in therapy-resistant leukemias“
12:00 – 13:00 Assoc. Prof. Kim Theilgaard-Mönch, Biotech Research & Innovation Centre, University of Copenhagen
Tittle and abstract to be announced soon
Presenter: Assoc. Prof. Francesca Sacco, Department of Biology, University of Rome Tor Vergata
Title: A systems biology approach to identify vulnerabilities in therapy-resistant leukemias
Abstract: In this presentation, I will show how an integrated systems biology approach combining mass spectrometry–based phosphoproteomics, multiparametric profiling, and network modeling can be used to uncover mechanisms of therapeutic resistance in leukemia. First, I will focus on FLT3-ITD acute myeloid leukemia, demonstrating that the position of the ITD insertion reshapes signaling networks and subcellular proteome organization, thereby determining response to tyrosine kinase inhibitors. I will show how this analysis identifies novel molecular vulnerabilities. Next, I will briefly present how similar phosphoproteomic and network-based strategies reveal BCR::ABL1-independent resistance mechanisms in chronic myeloid leukemia and enable the identification of novel draggable targets eradicating resistant cells. Finally, I will present a new project where we aim to increase leukemic cell immunogenicity by pharmacologically manipulating key signaling pathways.
Presenter: Assoc. Prof. Kim Theilgaard-Mönch, Biotech Research & Innovation Centre, University of Copenhagen
Title:
Abstract:
NB