CMYC-Seminar: “The dual specificity MAP kinase phosphatase DUSP2 acts as distal regulatory node in T Cell signalling” by Professor Ole Morten Seternes

Welcome to the upcoming seminar holdt by Professor Ole Morten Seternes, Group Leader of the Cell Signalling and Targeted Therapy Research Group, Department of Pharmacy, UIT The Arctic University of Norway.

Tittle: The dual specificity MAP kinase phosphatase DUSP2 acts as distal regulatory node in T Cell signalling

Time: 22nd October 2025. 14:00 – 15:00

Place: Room B307, 3rd floor, Sentralblokken, Haukeland University Hospital

Abstract:

The dual-specificity MAP kinase phosphatases (MKPs) family plays a critical role in the dephosphorylation and inactivation of various MAP kinases in mammalian cells and tissues. MKPs not only provide a mechanism for spatiotemporal feedback control of these essential signalling pathways but also facilitate crosstalk between distinct MAP kinase pathways and other key signalling modules. The ten mammalian MKPs differ in their substrate specificity and subcellular localization. Several MKPs have been implicated in regulating MAPK signalling in T cells. However, studies utilizing genetic mouse models have yielded conflicting results regarding which MKP members contribute to this regulation. This prompted us to re-examine the role of MKPs in controlling MAPK signalling using a human T cell model. Our findings suggest that DUSP2 regulates early MAPK activation in these cells and may function as a part of a distal regulatory node in T cell signalling.